Xiaoyu Niu, MD
Department of Obstetrics and Gynecology, West China Second Hospital of Sichuan University, Chengdu, Sichuan, China
After graduated from the West China University of Medical Sciences and received her Master Degree of Gynecology and Obsterics Medicine in 1998, Prof.Niu had been a resident at the Department of Obstetrics and Gynecology in the Second Affiliated Hospital of West China University of Medical Sciences for two years.
Soon after that, Prof. Niu was trained as Fellow (MDGO) at Sichuan University (obtaining the degree of Medical Doctor of Gynecologic Oncology) and Attending Physician at Department of Obstetrics and Gynecology in West China the Second Hospital of Sichuan University (WCSUH-SCU). From 2007 to 2009, Prof. Niu was trained as Clinical Fellow at Division of Gynecology Oncology in McGill University of Canada. From 2006 to 2015, she had been the Associate Professor at WCSUH-SCU and since after was promoted to be the professor in gyneoncology and urogynecology, and now is the Vice President in medicine administration.
Prof. Niu’s dedication to Gynecology Oncology and Urogynecology has been recognized in dozens of awards for scientific investigation and scholarship, including being the academic and technical leader of Sichuan Province, academic and technical leader of the Sichuan Provincial Health Development Planning Commission, the standing vice president of the Sichuan Reproductive Health Association, deputy secretary and general executive director of maternal and child health branch of Sichuan Hospital Management Association, the chairman of the association of pelvic disorder in the Sichuan provincial Preventive Medicine Committee, the director of China Health Care International Exchange Promotion Association maternal and child health care association pelvic floor health medicine alliance, the member of the urine control group of the Department of Urology in Sichuan Medical Association, the member of the Chinese Medical Association of gynaecology and obstetrics branch, member of the China Cancer Association (CSCO), member of the Canadian Gynecologic Oncology Committee, member of gynecologic endoscopy group in Sichuan Province. What’s more, she gained the Second Grade Award for Young Teacher Lecture Contest in Sichuan University in 2004, the Second Grade Award for Young Teacher’s teaching method Contest in Sichuan University in 2004, the Third Grade Award for Young Teacher’s English teaching Contest in Sichuan University in 2005, the honorable title of Outstanding Teacher in Sichuan University in 2004, 2015 and 2017.
As an active researcher, Prof. Niu has published more than 40 scientific papers and joined many research projects, including the research on precise treatment for women with pelvic floor dysfunction, effect of numb family protein on self-renewal and differentiation of epithelial ovarian cancer stem cells and its regulatory mechanism and so on. Recently, the main objective of Professer Niu’s research is to understand the gynecologic cancers through metabolism and how these research findings contribute to the clinical treatment. Research in her laboratory includes the following areas:
1) Inhibiton of cervical tumorgenesis via exogenous metabolism. She is actively investigating how vaginal flora disturbance may contribute to the cervical cancer by modifying metabolism. Her previous work has demonstrated the pattern of vaginal microbiota in different pathological conditions, screened bacterium candidates associated with HPV clearance and cervical tumorgenesis and identified a specific bacteriumas candidate to accelerate cervical tumorgenes. To further understand the role of this becterium in tumorgenesis, she is developing an in vivo model looking at the crosstalk between bacterium and cervix in the view of changed endogenous and exogenous metabolite.
2) Screen of biomarkers for gynecologic cancers based on integrative omics analysis. An pressing question in the field of ovarian cancer research is to find sensitive and reliable biomarkers for early diagnosis. Previous work in her laboratory has established the standard operating procedure for proteomics and lipidomic. Ongoing research is directed to screen biomarkers in tissue and plasma.
3) Explore the role of lncRNA-protein interaction in gynecologic cancers. Her previous work showed an epigenetic transcription switch (ETS) that controls tumorigenesis in human cancer. The ETS involves the tumor-suppressor protein that binds to proto-oncogene promoters and switches off transcription, and a RNA molecule, usually a long noncoding RNA (lncRNA), that binds to the protein and releases it from the promoters, switching on proto-oncogene transcription. She is currently investigating more lncRNAs that binds to the tumor-suppressor protein and trying to assort the candidate lncRNAs by cancer type.